- Safety & Security Systems & Consultants, Louisville
- Safety Equipment & Supplies, Louisville
- Sales & Marketing Consultant, Louisville
- Sandwich Shop Restaurants, Louisville
- Satellite Technology & Space Research, Louisville
- Savings Banks, Louisville
- School - Catholic, Louisville
- School - Christian, Louisville
- Science & Research, Louisville
- Scientific & Research Professionals, Louisville
- Scientific Services, Louisville
- Scientists, Louisville
- Scrap & Waste Materials, Louisville
- Screen Houses, Louisville
- Screen Printing, Louisville
- Search & Rescue, Louisville
- Secondary Schools, Louisville
- Security Brokers & Dealers, Louisville
- Security Consultants, Louisville
- Security Investigative Services, Louisville
- Security Services, Louisville
- Seed & Grain Cleaning, Louisville
- Seismographic Service, Louisville
- Semiconductors & Equipment, Louisville
- Sewer & Drain Cleaning & Repair, Louisville - Drain Cleaner & Installation Services
- Shirts & T-Shirts, Louisville
- Shoe Dyers, Louisville
- Shoe Repair & Shoeshine Parlors, Louisville
- Shoe Repair Shops, Louisville
- Shopping & Shopping Services, Louisville
- Sign Equipment & Supplies, Louisville
- Signs, Louisville
- Skating Supplies, Louisville - Ice, Inline, Speed, Figure & Roller Skates
- Ski Shops - Equipment & Supplies Sales & Rental, Louisville
- Ski, Snowboard & Snowmobile Shop - Equipment Rental & Services, Louisville
- Skin Care & Cosmetology Salons, Louisville
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- Skin Care Products & Treatments, Louisville
- Small Appliances, Louisville
- Snacks & Desserts, Louisville
- Soccer Equipment & Supplies, Louisville
- Social Science Research Professionals, Louisville
- Social Services & Welfare, Louisville
- Social Workers & Services, Louisville
- Societies & Foundation Associations, Louisville
- Solar Products & Services, Louisville
- Sound Systems & Equipment Rental & Leasing, Louisville
- Sound Systems, Microphones & Equipment, Louisville
- Special Coatings, Louisville - Protective Coatings
- Special Interest Schools Or Instruction, Louisville
- Specialty Animal Services, Louisville
- Specialty Communication Companies & Services, Louisville
- Specialty Stores, Louisville
- Speech & Hearing Specialists, Louisville
- Speech Pathologists, Louisville - Speech & Language Therapy
- Sporting & Recreational Camps, Louisville
- Sporting Goods Stores, Louisville
- Sports Medicine, Louisville - Doctors, Physicians & Surgeons
- Sports Promoters & Managers, Louisville
- Sports Promotions & Special Events, Louisville
- Sports Schools & Training Camps, Louisville
- Staffing & Support Services, Louisville
- Steak House Restaurants, Louisville
- Stock Photographers, Louisville
- Stocks & Bond Brokers, Louisville
- Stucco Siding Contractors, Louisville - Stucco Repair & Installation
- Stucco Siding, Granite & Grouting Contractors, Louisville
- Substance Abuse Clinics, Louisville - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Summer Camps, Louisville
- Surveyor Services, Louisville - Surveying Service
- Sushi Restaurants, Louisville
- Swimming Pools, Louisville
- Synthetic Resins & Rubber, Louisville
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